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Skip anything that compounds gastric slowing or GI irritation: high-dose iron without a documented deficiency, large single doses of magnesium oxide, and stimulant "fat burners" stacked on a drug already suppressing appetite

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Additionally, by pre-treating with the GRP receptor antagonist RC-3095, they found that GRP also plays a partial role in metformin-induced GLP-1 secretion

Some GI reactions are moderate to severe and induce the patient to quit therapy

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Lee YS, Park MS, Choung JS et al (2012) Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes